Secretary of State Marco Rubio leaves for his first overseas trip as the nation’s top diplomat on Saturday. Rubio's first stop on the six-day visit is Panama as he sets out on pursuing President Donald Trump’s geopolitical agenda.

Trump used his inaugural address to proclaim his intent to "take back" the Panama Canal, and in a call with reporters on Friday, Special Envoy for Latin America Mauricio Claver-Carone said Rubio’s chief purpose of the trip would be in re-establishing a "Golden Age" for America.

"This trip signifies… that era of American greatness and the Golden Age," he said, adding that "the 21st century will also be an American century."

MARCO RUBIO LAYS OUT AMERICA FIRST AGENDA IN NEW OP-ED, SAYS DAYS OF NEGLECTING US ‘END NOW’

Claver-Carone pointed out that Rubio’s trip to Latin America is the first time a secretary of state has traveled to the region as their first official visit abroad in over 100 years. 

"Last time that happened, I believe, was in 1912, when Philander Chase Knox went to Panama… to oversee the conclusion of the Panama Canal’s construction and operations," he told reporters. "What a great message to harken back to that Golden Age of the Americas, as President Trump himself has mentioned."

Rubio is scheduled to meet with Panamanian President José Raúl Mulino.

The pair are expected to discuss migration, combating drug trafficking and China’s presence in the Panama Canal, which Rubio and Trump have argued has become overrun by Chinese companies operating at either end of the crucial waterway.

The Trump administration has argued that the Chinese Communist Party’s (CCP) tight grip over all Chinese companies means that, in extension, the CCP is operating out of the canal and could, in theory, close it to U.S. trade if it chose to — posing a significant security threat. 

TRUMP OFFICIAL TRAVELS TO VENEZUELA TO NEGOTIATE DEAL FOR DEPORTING TREN DE ARAGUA GANG MEMBERS

Mulino has repeatedly denied that Chinese companies have any influence over the operations of the Panama Canal, and on Thursday said he would not be negotiating ownership of the canal with Rubio.

"It’s impossible, I can’t negotiate," Mulino said during a Thursday press conference when asked about negotiating control of the canal, The Associated Press reported. "That is done. The canal belongs to Panama."

Mulino apparently claimed confusion over control of the canal was attributed to his predecessor, who severed ties with Taiwan and established diplomatic relations with China in 2017, eventually allowing a Hong Kong consortium to operate ports at both ends of the canal.

Panama maintains that it controls the canal.

Claver-Carone argued that Chinese companies control "everything from force and logistics to telecommunications, infrastructure, and otherwise," which he said is not only a security threat to U.S. interests in the canal, but to the national security of Panama and the Western Hemisphere.

Rubio is also slated to visit El Salvador, Costa Rica, Guatemala and the Dominican Republic, where he will meet with the presidents of each nation before returning to the U.S. on Thursday. 

Addressing Chinese influence in these countries, along with gang violence, migration and drug trafficking, will also be top of Rubio’s agenda.

Secretary of State Marco Rubio paused all U.S. foreign assistance funded by or through the State Department and U.S. Agency for International Development (USAID) to allow the Trump administration to review if the money puts "America First."

On Sunday, the State Department released a statement about falling in step with President Donald Trump’s executive order to reevaluate and realign foreign aid from the U.S.

"Consistent with President Trump’s Executive Order on Reevaluating and Realigning United States Foreign Aid, Secretary [Marco] Rubio has paused all U.S. foreign assistance funded by or through the State Department and U.S. Agency for International Development (USAID) for review," the statement read. "He is initiating a review of all foreign assistance programs to ensure they are efficient and consistent with U.S. foreign policy under the America First agenda. President Trump stated clearly that the United States is no longer going to blindly dole out money with no return for the American people."

The statement continued, saying the review and alignment of foreign assistance on behalf of taxpayers is a "moral imperative," adding that Rubio is proud to protect America’s investment "with a deliberate and judicious review" of how the money is spent on aiding foreign countries overseas.

AFTER RAUCOUS FIRST WEEK IN OFFICE, DONALD TRUMP TO KEEP HIS FOOT ON THE GAS

"The implementation of this Executive Order and the Secretary’s direction furthers that mission," the statement read. "As Secretary of State Marco Rubio has said, ‘Every dollar we spend, every program we fund, and every policy we pursue must be justified with the answer to three simple questions: Does it make America safer? Does it make America stronger? Does it make America more prosperous?’"

The announcement comes after the Trump administration ordered staffers with USAID to stop providing foreign aid worldwide or face "disciplinary action" for not complying.

Reuters reported that the Trump administration sent a sharply-worded memo to more than 10,000 staff members at USAID on Saturday, offering a "stop-work" directive from Friday that put a freeze on U.S. foreign aid around the world.

TRUMP ADMINISTRATION NEEDS MORE PLANES TO CARRY OUT DEPORTATIONS: REPORT

The wire service reviewed the memo and said it laid out expectations for the workforce on how to achieve Trump’s goals to put "America First."

"We have a responsibility to support the President in achieving his vision," Ken Jackson, assistant to the administrator for management and resources wrote in the internal memo, titled "Message and Expectation to the Workforce."

"The President has given us a tremendous opportunity to transform the way we approach foreign assistance for decades to come," the memo added. Reuters reported that it confirmed the authenticity of the memo with several sources.

SPEAKER JOHNSON INVITES TRUMP TO ADDRESS CONGRESS AMID BUSY FIRST 100-DAY SPRINT

Trump ordered a 90-day pause in foreign aid just hours after taking office, to review if the funding was in line with his foreign policy priorities.

On Friday, the State Department issued a pause on aid worldwide.

The U.S. is the largest donor of aid globally. During fiscal year 2023, the U.S. dispersed $72 billion in assistance. It also provided 42% of all humanitarian aid tracked by the United Nations in 2024.

Fox News Digital has reached out to USAID for comment.

Reuters contributed to this report.

Secretary of State Marco Rubio told Chinese Foreign Minister and Director of the CCP Central Foreign Affairs Commission Wang Yi that the Trump administration will put the "American people first" and advance U.S. interests in its relationship with China, according to a readout of the call from spokesperson Tammy Bruce. 

The meeting was the first between Rubio and Wang since the former Florida senator was unanimously approved by the Senate this week to become President Donald Trump’s first Cabinet official following Monday's inauguration. 

"The Secretary also stressed the United States’ commitment to our allies in the region and serious concern over China’s coercive actions against Taiwan and in the South China Sea," Bruce said. "The Secretary also discussed other issues of bilateral, regional, and global importance with his Chinese counterpart." 

MARCO RUBIO HEADING TO PANAMA ON FIRST TRIP AS SECRETARY OF STATE: ‘WE WON’T CONTINUE TO IGNORE THE REGION'

Wang told Rubio during the call that he hoped he would "conduct" himself well and "play a constructive role in the future of the Chinese and American people and in world peace and stability." 

He added that Trump and Chinese President Xi Jinping had already set the tone for U.S.-Chinese relations. 

TRUMP, CHINA'S XI SPEAK ON PHONE AHEAD OF INAUGURATION

"The teams of both sides should implement the important consensus of the two heads of state, maintain communication, manage differences, expand cooperation, promote the stable, healthy and sustainable development of China-U.S. relations, and find the right way for China and the United States to get along in the new era," Wang said.

MARCO RUBIO CLASHES WITH NBC ‘TODAY’ HOST WHEN PRESSED ON TRUMP'S JAN. 6 PARDONS

Trump has threatened China with 10% tariffs on imports over its role in fentanyl trafficking, starting as early as Feb. 1, and Rubio called the country the gravest threat to the U.S. during his confirmation hearing. 

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Trump n Thursday told the World Economic Forum virtually that he and Xi have "always had a great relationship," and all his administration wants is "fairness. We just want a level playing field."

In one of the first moves of his administration, President Donald Trump signed an executive order taking drastic steps to crack down on the violent Venezuelan migrant gang "Tren de Aragua," which has been terrorizing American cities in recent months.

Also known as "TdA," Tren de Aragua is a Venezuelan criminal group present in over a dozen U.S. cities. The group has ties to the socialist Venezuelan dictator Nicolás Maduro and according to experts, is being used as a tool of asymmetric warfare to sow chaos and discord in the U.S.

Jose Gustavo Arocha, a former high-ranking Venezuelan military official and senior fellow at the U.S.-based Center for a Secure Free Society, told Fox News Digital that Trump’s order was an "extraordinary move" that is the "first good step in the route to neutralize TdA."

The order – which is titled "Designating Cartels And Other Organizations As Foreign Terrorist Organizations And Specially Designated Global Terrorists" – instructs newly confirmed Secretary of State Marco Rubio to move to designate Tren de Aragua, as well as Mexican gang MS-13 and other migrant gangs as "foreign terrorist organizations."

WHO IS TREN DE ARAGUA? VICIOUS VENEZUELAN GANG 'FOLLOWING IN THE PATH OF MS-13' IN AMERICA

A foreign terrorist designation expands the government’s ability to crack down on criminal groups operating in the U.S., allowing all government agencies, including the Department of the Treasury, to target that group from every angle.  

The order states that these groups "present an unusual and extraordinary threat to the national security, foreign policy, and economy of the United States," and invokes the International Emergency Economic Powers Act (IEEP) to declare a national emergency to "deal with those threats."

"It is the policy of the United States to ensure the total elimination of these organizations’ presence in the United States and their ability to threaten the territory, safety, and security of the United States through their extraterritorial command-and-control structures, thereby protecting the American people and the territorial integrity of the United States," reads the order.

The order gives Rubio 14 days to make policy recommendations – in consultation with the secretaries of the Treasury and Homeland Security as well as the U.S. attorney general and director of National Intelligence – to make a recommendation regarding the designation of TdA, MS-13 and any other group as a foreign terrorist organization.

TEXAS GOV. ABBOTT DESIGNATES VENEZUELAN GANG, TREN DE ARAGUA, AS A FOREIGN TERRORIST ORGANIZATION

According to Arocha, this move could spell the beginning of the end for TdA’s reign of terror in the United States.

"This executive order that Trump signed is perfect to neutralize unconventional tools that were made by the Venezuela regime," he said. "The TdA is an asymmetrical and unconventional tool to harm the United States, [and] not only the United States, all the region … [so] you have to use unconventional tools, too."

Joseph Humire, executive director of the Center for a Secure Free Society who in 2024 authored a report on how to dismantle TdA, explained to Fox News Digital that designating these groups as foreign terrorist organizations places them "at the highest level" of U.S. national security interest, meaning their funding and any organizations enabling them can be targeted as well.

"Trump just put all of them on notice," said Humire. "This said: ‘We know you're here; we know you're up to no good and we're going to come after you.'"

TREN DE ARAGUA BELIEVED TO BE BEHIND MURDER OF IMMIGRATION OFFICIAL NEAR BORDER

"Now critics may say, well, he's going to create a war on terror or drugs, and it's really a reaction of fear. They say: 'Oh, you know, these guys are so dangerous.' And what you know about criminality, whether it's terrorism or any kind of criminality, is that they only respond to strength. They prey on fear. If they think you're scared to attack you more," he said. "So, by showing this strength, it's the first action of deterrence."

In addition to sending a message of strength, Humire said the executive order signals that there will be "meaningful action taking place really, really soon to start to arrest and dismantle" TdA’s presence in the U.S.

Andrew Arthur, a law and policy expert at the Center for Immigration Studies, told Fox News Digital that one of the most important aspects of designating TdA a foreign terrorist organization is enabling the U.S. government to target TdA’s funding, which he said can essentially "bleed them dry."

CLICK HERE FOR MORE IMMIGRATION COVERAGE

"Money is the lifeblood of these organizations," he said. "It's really the funding element of all this that is crucial to going after a terrorist organization, because if you cut them off from the money, they're not going to be able to pay people. They're not going to be able to pay bribes to corrupt officials, they are not going to be able to pay their foot soldiers, are not going to be able to buy the big guns and the things that they used to operate."

"It's not just the guy with the AK-47 or the guy with the IED that's a terrorist. It's all those people that helped to make that possible," he went on. "So, when you designate them as terrorist organizations, in addition to going after the keepers or the kingpins of these organizations and the various foot soldiers that they employ, you can also go after the individuals who provide material support."

Secretary of State Marco Rubio got into a tense exchange with NBC's "Today" show on Tuesday after one of the network's hosts repeatedly asked him about President Trump's sweeping Jan. 6 pardons.

Following a quick introduction, NBC immediately played a 2021 clip of Rubio condemning the Jan. 6 attack on the Capitol.

"Vladimir Putin loved everything that happened here today because what happened is better than anything he could have ever come up with to make us look like we're falling apart," he said at the time.

After the video ended, NBC host Craig Melvin asked Rubio what message the pardons send to the rest of the world.

FLASHBACK: MEDIA ATTACKED TRUMP FOR FLOATING PREEMPTIVE PARDONS IN 2020 BEFORE BIDEN DID SO FOUR YEARS LATER

Rubio replied that he would not "engage in domestic political debates" with the media and could not in his role as the head of the State Department.

"I hope you guys all understand that my days – at least in the time at the Department of State – of engaging in domestic politics will be put aside as I focus on the affairs the United States has around the world and the engagements we have to have to make our country a safer, stronger, more prosperous place," he later added.

Melvin again pressed Rubio on the pardons – questioning if Trump's decision would give the now freed defendants incentive to foment a future attack.

TRUMP TO TAKE MORE THAN 200 EXECUTIVE ACTIONS ON DAY ONE

"I think it's unfortunate, you know, our first engagement as I agree to come on this morning with you. I'm going to be working on foreign policy issues, and you want to revisit these issues that are going on in domestic politics. I'm just – it's not going to happen," Rubio said. "If you have questions for me about foreign policy and engaging in the world, I'd be happy to talk to you about those."

Rubio similarly stressed his "singular" focus on foreign policy when asked about the pardons on "CBS Mornings" and ABC's "Good Morning America."

TRUMP TO DEPLOY MILITARY TO BORDER, END BIDEN PAROLE POLICIES IN FLURRY OF DAY ONE EXECUTIVE ORDERS

Trump pardoned nearly all Jan. 6 defendants on Monday night after promising at his inaugural parade to sign an executive order on the matter.

Sitting at the Resolute desk in the Oval Office, Trump signed off on releasing more than 1,500 charged with crimes stemming from the Jan. 6, 2021, attack at the U.S. Capitol. The order requires the Federal Bureau of Prisons to act immediately on receipt of the pardons.

Fox News' Diana Stancy and Jamie Joseph contributed to this report.

Florida Sen. Marco Rubio was confirmed unanimously by the Senate to be the next secretary of state, making him the first of President Trump's Cabinet picks to receive congressional approval.

Rubio, a senator since 2011, was confirmed during a floor vote by the full Senate Monday night, several hours after Trump took his oath of office earlier in the day. The full Senate floor vote occurred following a separate vote by the Senate Foreign Relations Committee, which also voted unanimously in favor of Rubio's nomination Monday.  

Rubio enters his role as secretary of state with a strong foreign policy background as a longtime member of the Senate's Foreign Relations and Intelligence Committees. He is also a first-generation Cuban American.

DESANTIS ANNOUNCES CHOICE FOR SENATE APPOINTMENT AFTER RUBIO'S EXPECTED RESIGNATION 

His road to confirmation has been less controversial than many of Trump's other Cabinet picks. At Rubio's first confirmation hearing last week in front of the Foreign Relations Committee, the committee's top-ranking Democrat, Sen. Jeanne Shaheen of New Hampshire, said she thought Rubio possessed "the skills" and is "well-qualified" to serve as the next secretary of state. She echoed this sentiment Monday evening as well before the full Senate vote.

"I've had a good working relationship with Sen. Rubio for many years, and I was very impressed during his hearing by his grasp of policy," Shaheen said Monday evening. "While we may not always agree, I believe he has the skills, knowledge and qualifications to be secretary of state."

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Rubio expressed during his initial confirmation hearing last week that under Trump the State Department's "top priority" will be to put America first. 

"This will not be easy," Rubio said. "And it will be impossible without a strong and a confident America that engages in the world, putting our core national interests, once again, above all else."

Rubio will face some major challenges heading into his new role, notably the ongoing Russian invasion of Ukraine and the war between Israel and Hamas in Gaza.

Rubio described the fighting between Ukraine and Russia as a "stalemate" that "has to end" during his confirmation hearing last week, adding that under Trump's proposed peace deal both countries will have to make "concessions." Meanwhile, despite Trump's past criticisms of the North Atlantic Treaty Organization (NATO), Rubio called the alliance "very important" and insisted that Trump was also a NATO supporter.

On Gaza, Rubio supported Israel's actions to defend itself against Hamas but stopped short of indicating one way or the other if he thought Israel's annexation of parts of the West Bank was something he supported. 

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"The idea would be that there not be conflict and the people could live side-by-side with one another without being in conflict and with the ability to pursue prosperity," Rubio said. "Sadly and unfortunately the conditions for that to exist have not been in place for a substantial period of time."

Rubio also repeatedly singled out China during his remarks in front of the Senate Foreign Relations Committee last week. "We welcomed the Chinese Communist Party into this global order. And they took advantage of all its benefits. But they ignored all its obligations and responsibilities," Rubio posited at his hearing. "Instead, they have lied, cheated, hacked and stolen their way to global superpower status, at our expense."

While Rubio did not face significant opposition to his confirmation, some Trump-aligned Republicans have expressed disdain over Rubio's willingness to certify the results of the 2020 election that Trump alleged was "stolen" from him. Sen. Rand Paul, R-Ky., who has been an outspoken supporter of less U.S. intervention, also questioned Rubio's hawkish stance on American intervention amid his confirmation to be secretary of state.

Florida Attorney General Ashley Moody, who is slated to become a U.S. senator, is calling for an audit of the Federal Reserve, pledging to vocally oppose government spending, and declaring that she will fight to bolster the border and remove individuals who enter the U.S. illegally.

With Sen. Marco Rubio, R-Fla., poised to soon leave office to serve as Secretary of State in the new Trump administration, Florida Gov. Ron DeSantis announced Moody as his pick to replace Rubio in the U.S. Senate. 

And with even some Democrats planning to support confirmation, Rubio is likely to sail through the confirmation vote.

"Here's a priority of mine in the Senate: our inflation has been fueled by the Federal Reserve. We must audit the Fed!" Moody declared in a post on X.

DESANTIS ANNOUNCES CHOICE FOR SENATE APPOINTMENT AFTER RUBIO'S EXPECTED RESIGNATION

"As Florida’s next U.S. Senator, I will work tirelessly to reduce the bloat of Washington and speak out loudly against government spending," she noted in another post. "Like we've done in Florida, this country needs to cut spending and get fiscally responsible. I look forward to working with DOGE, and I will work hard to leave the next generation of our country on a much stronger financial footing."

When discussing her role in confirming judges and justices, she specifically mentioned Supreme Court Justices Clarence Thomas and Samuel Alito.

"As a former judge, I will take my role confirming judges and justices seriously to ensure that, like Justices Thomas and Alito, they share the values and concepts of law as our Founding Fathers understood them," she said in a tweet. "I will work through the Senate confirmation process to ensure those who get confirmed are strong nominees and know that it is their duty to interpret the Constitution as it is written."

WHO IS ASHLEY MOODY? MEET THE SENATE'S NEWEST MEMBER FROM FLORIDA

Sharing Moody's post, DeSantis called Alito and Thomas "the gold standard."

"In the U.S. Senate, I will support President @realDonaldTrump and fight for legislation that strengthens the border, builds the wall, and removes those who entered unlawfully," Moody noted in a tweet.

DESANTIS TOUTS FLORIDA'S ‘FUTURE WAY OF THINKING,’ VOWS STATE WILL ‘DO OUR DUTY’ TO HELP INCOMING TRUMP ADMIN

DeSantis responded, declaring, "Make Illegal Immigration Illegal Again."

Gov. Ron DeSantis, R-Fla., revealed on Thursday who he plans to appoint to the Senate once Sen. Marco Rubio, R-Fla., resigns, as he is expected to be confirmed to be President-elect Donald Trump's Secretary of State after his inauguration. 

The governor selected Florida Attorney General Ashley Moody to be the next senator. 

CONFIRMATION DELAYS STACK UP FOR TRUMP NOMINEES AS PAPERWORK LAGS IN FEDERAL OFFICES

Moody has been a key ally of DeSantis in the state and worked in tandem with him to facilitate his agenda as governor. 

During his Thursday announcement, DeSantis said "So this is something that I thought about long and hard. We did a lot of research. We got a number of great candidates throughout the state of Florida, and many of them, I think, could have done a good job. But the final criteria I used was because you can say all those things and say you stand for it—I wanted somebody with a demonstrated record of delivering results on those important issues. Talk is cheap."

"We need people that have demonstrated fidelity to these principles with their actions. So that is why today I'm proud to announce that I am selecting our Attorney General, Ashley Moody, to serve as our next U.S. Senator," he told attendees. 

Moody accepted the challenge and thanked the governor for choosing her. "Thank you so much. I will bring the same persistence and passion and tenacity as a United States Senator that I have brought as Florida's Attorney General," she said.

DEM SENATOR WHO BASHED HEGSETH'S QUALIFICATIONS STANDS BY DOD SEC WHO OVERSAW BOTCHED AFGHAN WITHDRAWAL

"If you have worked with me and fought with me over the last six years, you know, I don't think of this as a job. I think of it as a calling," she explained. 

When asked about potentially taking on the role on "Fox and Friends First" in November, Moody previously said, "I have my hands full here as attorney general, and I'm incredibly focused on this job, working on behalf of Floridians, making sure I'm protecting the autonomy of the state and pushing Washington out of our business and holding them accountable. Of course, I love … being in leadership, working with President Trump, working with Governor DeSantis. And I hope to continue working on behalf of Floridians."

Initially, Trump and Sens. Katie Britt, R-Ala., and Rick Scott, R-Fla., endorsed Trump's daughter-in-law and former RNC Co-Chair Lara Trump to succeed Rubio. However, she later withdrew her name from consideration. 

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"After an incredible amount of thought, contemplation, and encouragement from so many, I have decided to remove my name from consideration for the United States Senate," she wrote on X. 

Following Thursday's announcement, Scott congratulated Moody on X. "I welcome @AGAshleyMoody to the United States Senate! Ashley has done an incredible job fighting for Floridians and keeping our communities safe as Attorney General. I have no doubt she will do an incredible job as senator!" he said. 

DeSantis added on Thursday that he expects to appoint Moody to the Senate the afternoon of January 20, after Trump is sworn in to office. 

"We anticipate Senator Rubio to get confirmed very quickly after the inauguration of the 47th president, President Trump," he said. 

He further thanked Rubio for his service as a senator. "I want to thank Senator Rubio for his service in the United States Senate. I think he will serve the country ably as Secretary of State and, we need it because, the last four years has been a total disaster, under the Biden-Harris administration," the governor said. 

Florida's Republican Sen. Marco Rubio sailed through his confirmation hearing with the Senate Foreign Relations Committee on Wednesday, all but assuring he will assume the role of top diplomat under the new Trump administration later this month.

Rubio’s confirmation hearing — a process usually full of verbal diatribes, strong political agendas and illusive answers — was full of pleasantries, with both Democratic and Republican lawmakers applauding his work in the Senate and his in-depth knowledge of complex issues across the globe.

Here were the top moments from Rubio’s hearing.

RUBIO TO PITCH FOREIGN POLICY CREDENTIALS TO SENATE AS HE VIES TO BECOME AMERICA'S TOP DIPLOMAT

While Rubio may have been welcomed by his Senate colleagues, his hearing wasn’t entirely contention-free.

The secretary of state-hopeful’s opening remarks were interrupted by several protesters affiliated with a group known as Code Pink, who were protesting the Israel-Hamas war and wore pink shirts that read "stop killing the children of Gaza."

Two of the demonstrators forced to leave the chamber were male, before a female protester also stood up and yelled out in Spanish. 

She was quickly escorted from the room and the hearing promptly restarted.

"I get bilingual protesters," Rubio said to the panel of senators with a grin before resuming his remarks.

Rubio’s quip about the protesters appeared to set the tone for his hearing.

Though Rubio faced tough questions about detailed geopolitical issues on nearly every continent, lawmakers on both sides of the aisle also joked around with their Senate colleague.

Sen. Rick Scott, R-Fla., introduced Rubio at the top of the hearing and quipped that "finally" he will get to be the senior senator of Florida after the duo have served together in the upper chamber since 2019.

Sen. Cory Booker , D-N.J., drew chuckles when he said, "Sen. Rubio, the President [elect] made a great decision in choosing you. You’re a thought leader in foreign policy. I, however, don’t think most Americans know how great of a thought leader you are in NCAA, NFL and high school football, and I’m a little disappointed that you’re not going to the head of the NCAA right now."

To which Rubio replied, "Not yet," garnering laughs from the room.

In another bipartisan moment rarely seen during Cabinet nomination hearings, Sen. Tammy Duckworth, D-Ill., told a touching story from one of her first encounters with Rubio — a stark contrast to her questioning of defense secretary nominee Pete Hegseth the day prior. 

In 2018, not only was Duckworth relatively new to the upper chamber, but the soon-to-be new mom was also pushing the congressional body to change its rules and allow new parents to bring their infant onto the Senate floor during a vote.

Duckworth, who is physically disabled after surviving a 2004 RPG attack on her helicopter in Iraq, described rolling across the Senate floor in her wheelchair when she heard someone call out her name. 

"And you came running down from the top back of the Senate chambers to tell me, ‘I’m with you. I will support you’," she said. "And I just want to thank you for that kindness… It was a moment of true bipartisanship."

Rubio responded and said, "I think what I exactly said is, ‘What’s the big deal? This place is already full of babies,'" once again drawing laughs.

INTERNATIONAL UNDERWATER CABLE ATTACKS BY RUSSIA, CHINA ARE NO ‘MERE COINCIDENCE’ WARNS EU’S TOP DIPLOMAT

The five-hour hearing wasn’t all fun and levity, as Rubio was pressed on issues with major security implications like the war in Ukraine, China, NATO and Artic security.

Rubio surprised no one with his tough-on-China approach and his commitment to remaining a strong ally of NATO’s.

However, one area senators may have hoped Rubio would have come out more definitively was over what continued support for Ukraine may look like and how the incoming Trump administration will handle the question of Ukraine becoming a NATO member. 

Both Ukraine and Russia have signaled they are open to negotiating a cease-fire. But securing a lasting peace deal could be difficult as Ukraine entering the NATO alliance has been deemed a non-negotiable by both Kyiv — who wants the alliance’s security — and Moscow — which has fervently opposed Ukrainian NATO membership.

"The truth of the matter is that in this conflict there is no way Russia takes all of Ukraine. The Ukrainians are too brave, and fight too hard, and the country is too big," Rubio said.

But he added that "there’s no way Ukraine is also pushing these people [Russians] all the way back to where they were on the eve of the invasion."

Rubio pointed out that Ukraine will not be able to keep up with the sheer number of bodies that Russia can throw in to the war.

"It's important for everyone to be realistic. There will have to be concessions," he said. "This is not going to be easy. "[It's] going to require a lot of hard diplomacy."

TRUMP CABINET PICKS PAM BONDI, MARCO RUBIO, OTHERS FACED A FULL DAY OF QUESTIONS FROM SENATORS

The security threats surrounding China came up in nearly every issue Rubio was asked to address, including its growing presence in Africa and Latin America, its oppressive practices in the South China Sea, concerns over trade, human rights abuses, tech and its growing relationships with other adversarial nations.

But one issue newer to headlines as of late is China’s involvement in the Panama Canal.

"This is something that's existed now for at least a decade in my service," he said, referring to a 2017 trip he took to Panama. "Chinese companies control port facilities at both ends of the canal — the east and the west. And the concerns among military officials and security officials, including in Panama, at that point, [was] that could one day be used as a choke point to impede commerce in a moment of conflict."

"This is a legitimate issue that needs to be confronted," Rubio added.

The issue of Chinese control over the major waterway resurfaced earlier this month when Trump refused to say whether he would rule out military intervention in the Panama Canal.

Rubio was pressed on the subject multiple times, though he was clear that he was not yet at a point where he knew enough about the legal parameters of U.S. intervention in Panama to give a thorough response. 

Sen. Tim Kaine, D-Va., applauded Rubio for being "extremely well-prepared" for his confirmation hearing as the next secretary of state — a stark contrast to his tense engagement with Hegseth during the hearing a day prior.

"We're used to seeing nominees who know a lot about a couple of things, and sometimes, who know very little about virtually everything," he said. "But I think you've seen a hearing with a nominee who — agree or disagree with the points he's made — he's not talking out of a briefing book.

"He's not having a thumb through a binder to decide how to answer a particular question," Kaine continued. "I've always been struck by working with Sen. Rubio on this committee, since I came to the Senate in January 2013, that he has a very well-developed sense of the world and a passion in all corners of it."

Kaine's sentiment appeared to be shared by the entirety of the committee, and many of the senators expressed confidence that Rubio will be unanimously confirmed for the top job.

Florida Republican Sen. Marco Rubio, who was tapped to lead the Department of State under the second Trump administration, was repeatedly interrupted by protesters during his Senate hearing on Wednesday. 

One female protester was heard shouting at Rubio in Spanish, while at least two men, including one wearing pink, were seen being pulled out of the hearing by Capitol Police after shouting. 

"I get bilingual protesters," Rubio quipped after a protester yelled at him in Spanish, earning laughter from the crowd.

Ahead of the hearing kicking off on Wednesday morning, Fox News Digital spotted Code Pink protesters wearing bright pink with shirts reading, "hands of Iran," and "stop killing the children of Gaza." They also sported anti-Rubio stickers on their headbands and hats.

HEGSETH INTERRUPTED BY MULTIPLE PROTESTERS DURING SENATE CONFIRMATION HEARING

Protesters were warned by the chair of the Senate Foreign Relations Committee ahead of the hearing kicking off to not disrupt proceedings, saying they will be removed from the hearing and would not be permitted to a public hearing for at least a year. 

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"Distractions will include not only noise, not only standing up, not only holding up painted hands, painted signs. None of that will be allowed. If you do that, I'm going to pause the committee. I'm going to ask our friends, first of all, my, my faithful, Sergeant at Arms here -- who's, perhaps, tougher than the Capitol Police. But also the Capitol Police to assist. And, we will pause briefly … If you are removed, you'll not be permitted back into one of these public hearings for at least 12 months. And, that's the purpose of this is, as I've stated, and it's important work," Republican Idaho Sen. James Risch, chair of the Senate Foreign Relations Committee, said in opening remarks. 

A handful of President-elect Donald Trump's picks for his cabinet are facing Senate hearings this week ahead of his inauguration on Monday. 

Department of Energy Secretary nominee Chris Wright's confirmation hearing was also interrupted by protesters on Wednesday, who shouted if his policies would "put out the fires in LA."

Protesters also interrupted Pete Hegseth's Senate confirmation hearing on Tuesday, when he joined the Senate Armed Services Committee and he was grilled by lawmakers ahead of a committee vote and final confirmation vote on his nomination as secretary of Defense. 

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"Veterans are committing suicide and are homeless, but we send money to bomb children in Gaza," one female protester wearing fatigues shouted as she was escorted from the hearing, Fox News Digital video shows. 

An elderly man who was handcuffed with zipties was also seen being escorted out of the hearing. Another man, also appearing to wear fatigues, was seen being carried out by Capitol Police. 

Sen. Tom Cotton, R-Ark., asked Hegseth about the protesters during his hearing, including regarding the war in Israel that has been ongoing since 2023. 

"Another protester, and I think this one was a member of Code Pink, which, by the way, is a Chinese communist front group these days, said that you support Israel's war in Gaza. I support Israel's existential war in Gaza. I assume, like me and President Trump, you support that war as well," Cotton said. 

"I support Israel destroying and killing every last member of Hamas," Hegseth responded. 

Republican Florida Sen. Marco Rubio is bracing himself for the hot seat as he prepares to sit through the often-arduous confirmation hearing process on Wednesday with the Senate Committee on Foreign Relations as he vies to lead the State Department under the next Trump administration. 

Though Rubio is not expected to get off easy in front of the panel of his colleagues posed to pressure him on everything ranging from the war in Ukraine, conflict in the Middle East and a trade war with China, which Trump has threatened to drastically increase, he is expected to pass through more smoothly than other candidates Trump has slated for his Cabinet.

In an excerpt of Rubio's remarks obtained by Fox News Digital ahead of his address to the Senate body, he highlights the security threats that have emerged following the end of the Cold War and the belief that democracy could succeed across the globe and international free trade was the way of the future.

"While America far too often continued to prioritize the ‘global order’ above our core national interests, other nations continued to act the way countries always have and always will, in what they perceive to be in their best interest," the remarks read. "And instead of folding into the post-Cold War global order, they have manipulated it to serve their interest at the expense of ours."

"The postwar global order is not just obsolete; it is now a weapon being used against us," he added. 

Senate Democrat Whip Dick Durbin of Illinois already threw his support behind his Republican peer and on Monday said, "Sen. Rubio and I share many similar views on foreign policy and, as a result, have worked closely together in the Senate to move forward with legislation regarding human rights around the world."

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"I believe Senator Rubio has a thorough understanding of the United States’ role on an international scale, has served with honor on the Senate Foreign Relations Committee, and is a good choice to lead the State Department. I plan to vote yes on his nomination when it comes before the Senate," Durbin said in a statement after a meeting in which they discussed security issues involving Russia’s threat in the Baltic Sea and the NATO alliance. 

Trump announced his nomination of Rubio for the top diplomatic job in November, which the senior member on the Senate Foreign Relations Committee said was not only a "tremendous honor" but a "tremendous responsibility."

"The job of the secretary of state is to execute on the foreign policy set by the elected president of the United States. And I hope to have the opportunity to do it, if my current colleagues here in the U.S. Senate confirm me so," he told reporters on the Hill. 

But Rubio's commitment to execute the wishes of the executive office could also prove to be his most difficult hurdle, not only during Senate questioning but also in taking up the job should he be approved by the upper chamber. 

Trump has repeatedly made clear he expects unwavering loyalty from Cabinet members, advisers in the White House and even military leaders, and reports this week suggest the incoming administration may be planning on clearing house in the National Security Council to ensure the president is only surrounded by those who support his agenda, according to an Associated Press report. 

While Rubio and Trump see eye-to-eye on issues like U.S. support for Israel, remaining tough on China and opposing dictatorial powers in Latin America – all of which are unlikely to garner much opposition from Democrats in the Senate – there are issues that could prove tricky for the three-term senator to navigate.

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Rubio and Trump have a history of exchanging barbs, particularly during the 2016 presidential race.

The duo have long patched up their hostilities in large part because Rubio has more closely aligned himself behind Trump, a move that has meant he is no novice when it comes to walking the political tightrope between appeasing Trump and pursing issues important to him.

This balancing act became evident on the campaign trail when Rubio was asked about controversial comments made by the Trump camp when it came to U.S. support for Ukraine and how to end the now three-year war.

"I’m not on Russia’s side, but unfortunately the reality of it is that the way the war in Ukraine is going to end is with a negotiated settlement," Rubio said in a September interview with NBC’s "Meet the Press." 

Rubio dodged questions on whether he backed comments made by Vice President-elect JD Vance when he suggested Ukraine cede land to Russia and agree to a demilitarized zone along the current front lines.

Instead, he said, "I would be comfortable with a deal that ends these hostilities and that, I think, is favorable to Ukraine, meaning that they have their own sovereignty, that they don’t become a satellite state or a puppet state."

Rubio also backed Trump after concern mounted over the now-president-elect’s position on NATO when he said he would encourage any nation, including Russia, to "do whatever the hell they want" to any NATO nation not fulfilling their defense spending commitments.

"Donald Trump is not a member of the Council on Foreign Relations," Rubio told CNN’s Jake Tapper in February. "He doesn’t talk like a traditional politician, and we’ve already been through this. You would think people would’ve figured it out by now."

That said, Rubio in 2019 also helped reintroduce bipartisan legislation that would prohibit any president from unilaterally withdrawing from NATO without Senate approval, a move that Trump threatened during his first term and which remained a top concern that was echoed by Trump's former NSC adviser, John Bolton, during the latest presidential race. 

Rubio’s unwavering outward loyalty to the incoming president could be tested if he is questioned about the president-elect’s expansionist rhetoric, like acquiring Greenland and the Panama Canal through the use of the U.S. military. 

Fox News Digital could not reach Rubio’s office for comment on where he stands on U.S. intervention in Greenland, which is technically under the protection of NATO so long as it remains a territory of Denmark, as well as the Panama Canal, which the U.S. gave back to Panama in 1999 but which Trump has accused China of taking over.

Republicans will hold confirmation hearings this week for more than a dozen high-profile administration picks for President-elect Trump's next term, including those for Pete Hegseth, Sen. Marco Rubio, R-Fla., and Gov. Kristi Noem, R-S.D.

Hegseth, Trump's Secretary of Defense pick, will have one of the first hearings on Tuesday, when he will go before the Senate Armed Services Committee at 9:30 a.m. and face questions from both Democrats and Republicans. 

Rubio and Noem were tapped by Trump to be his Secretaries of State and Homeland Security, respectively. Noem will appear before the Senate Committee on Homeland Security and Governmental Affairs on Wednesday at 9 a.m., while Rubio is set to face the Senate Committee on Foreign Relations at 10 a.m. 

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Other Tuesday hearings include those for Doug Collins to serve as Secretary of Veterans Affairs and former North Dakota Gov. Doug Burgum for Secretary of the Interior. 

Trump also chose Pam Bondi for attorney general, John Ratcliffe to direct the Central Intelligence Agency (CIA), Russell Vought to lead the Office of Management and Budget (OMB), Sean Duffy for Secretary of Transportation and Chris Wright to be Secretary of Energy. Hearings for each of them will be on Wednesday. 

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Eric Turner, who Trump tapped to be his next Secretary of Housing and Urban Development (HUD), and Scott Bessent, whom the president-elect announced as his pick to lead the Treasury Department, have hearings scheduled for Thursday. 

The hearing blitz comes as Republicans prepare to confirm as many Trump nominees as they can, as quickly as they can. 

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Sen. Rand Paul, R-Ky., explained his hope to confirm his choices promptly, on "Maria Bartiromo’s Wall Street" on Friday, saying, "In the past, the minority party has not obstructed at least a handful of high-ranking Cabinet members to be approved in the first week. So I'm hopeful that Secretary of State, as well as Department of Homeland Security, will be approved either on the day of the inauguration, the day after or that week, as well as a few others — Department of Defense."

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"So, I'm hoping we get to it quickly and that we don't muddle it around. And I still have my fingers crossed that that's going to happen. As far as the two that I'm in charge of, I've seen no resistance on the Republican side. And some indication that we may get some Democrat support as well," he added. 

Republicans are particularly motivated to confirm Trump's national security team, especially in the wake of a recent terror attack in New Orleans, Louisiana, in which 14 were killed, and 35 people were injured. 

Lara Trump, President-elect Trump’s daughter-in-law, said Saturday she is removing herself from consideration for Florida Republican Marco Rubio’s seat in the U.S. Senate. 

"After an incredible amount of thought, contemplation, and encouragement from so many, I have decided to remove my name from consideration for the United States Senate," she wrote on X Saturday. 

The president-elect has nominated Rubio to be secretary of state. 

"I could not have been more honored to serve as RNC co-chair during the most high-stakes election of our lifetime and I’m truly humbled by the unbelievable support shown to me by the people of our country, and here in the great state of Florida," Lara Trump added.

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Trump, the wife of Eric Trump, the president-elect’s son, stepped down as co-chair of the Republican National Committee earlier this month.

" I have read so many of your kind messages and I cannot thank you enough," Lara Trump said, adding she has a "big announcement that I’m excited to share in January."

She said she remains "incredibly passionate about public service and (looks) forward to serving our country again sometime in the future. In the meantime, I wish Governor DeSantis the best of luck with this appointment."

The president-elect had previously pressed DeSantis to name Lara as Rubio's replacement, a source in his political orbit told Fox News Digital, but he later told reporters he didn't necessarily expect him to select her. 

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"That's his choice," the president-elect added. 

Rubio’s senate replacement will be appointed by Florida Gov. Ron DeSantis and will serve the remaining two years of Rubio's term. 

In 2026, the seat will be open for a full six-year term. 

Lara Trump had previously said she was "seriously considering" the position, although she wasn’t sure it was right for her. 

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DeSantis previously said he would make an appointment by early January. 

Lara Trump did not immediately respond to Fox News Digital’s request for comment.